trigeminal neuralgia and its response to micovascular decompression despite persistence of residual groove suggests that its the contact itself (or medium through which it is contacting e.g. vessel intima adventitia or the like) that permits transmission of abnormal electrical impulses that are interpreted as pain ( in this particular case)
maybe loss of CSF between tissues results in the pathological transmission
maybe vessels below a certain size use CSF and pulsatility physiologically.
so need to model the notion of transmission of current perpendicular to axon (i.e. a star source) and in calculating the activity via magnetic electroencephalography we choose as many vectors as possible 360deg around the axon instead of along the axon and map brain regions according to this star like behaviour to interpret the higher functions that enable multiple cognitive functions and associations at once (i.e. the ability to see patterns and apply experience from one setting to quite a different one successfully).
Could it be that as well as achieving the high surface area of the cortex , the reason for the sulci over the cortices is to facilitate further cross channelling brain-to-brain impulses faster than simple one dimensional neuronal impulses.
i.e. instead of modelling the brain as an electrical circuit like a complicated road network with roundabouts and traffic lights we need to add bridges all along the lengths between every road!
that might be what enables the leap from Penrose’s proof of brain non computability (i.e. non algorithmic nature-because one part “knows” about another part despite the absence of a wire (or axon) directly between the two (or more specifically before an impulse can reach another part via the axons…like a worm hole leaping across 3 dimensional space…the sulci (and maybe CSF) allow the leaps of information and speed up the processing power almost infinitely!
Is this why brain pulsatility is important..it is the measure of transverse information processing and by modelling a time variable one can selectively look at it on MRI and show a whole new type of brain activity from the simple cause-effect model that has driven this very regionalistic approach to neuroscience since the advent of functional MRI.
energy considerations make this vector model less attractive than the lowest energy along the axon but could it be that move outwards in all directions might not be as expensive as it sounds.